The Potential of Gut Microbiota in Prediction of Stroke-Associated Pneumonia

Background: Stroke-associated pneumonia (SAP) is a common stroke complication, and the changes in gut microbiota composition may play role. Our study aimed to evaluate predictive ability of for SAP. Methods: Acute ischemic patients were prospectively enrolled divided into two groups based on presence or absence The was characterized by 16S RNA Miseq sequencing. that differed significantly between incorporated conventional risk scores, Ischemic Stroke-Associated Pneumonia Score (AIS-APS), Age, Atrial fibrillation, Dysphagia, Sex, Stroke Severity (A2DS2). performances assessed terms area under curve (AUC), Net Reclassification Improvement (NRI), Integrated Discrimination (IDI) indices. Results: A total 135 enrolled, whom 43 had SAP (31%). short-chain fatty acids (SCFAs)-producing bacteria, such as Bacteroides, Fusicatenibacter, Butyricicoccus, decreased group. integrated models showed better (AUC = 0.813, NRI 0.333, p 0.052, IDI 0.038, 0.018, AIS-APS; AUC 0.816, 0.575, < 0.001, 0.043, 0.007, A2DS2) comparison differential genera 0.699) each score (AUCAISAPS 0.777; AUCA2DS2 0.777). Conclusions: lower abundance SCFAs-producing after acute associated with role prediction.